Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. ![]() ![]() As representative of the nervous system innate immune system, the current study examined changes in microglia following exposure to representative FRs, pentabromophenol (PBP), tetrabromobisphenol A (2,2’,6,6’,-tetrabromo-4,4’-isopropylidine diphenol TBBPA) and triphenyl phosphate (TPP). In this regard, reports of flame retardant (FR)-related effects on the innate immune system suggest process by which a spectrum of adverse health effects could manifest across the life-span. However, exposure related issues for susceptible populations, the developing, infirmed, or aged, remain given environmental persistence and home-environment detection. ![]() The predominant reliance on bromated flame retardants (BFRs) is diminishing with expanded use of alternative organophosphate flame retardants.
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